With Insteon Hub (2245-222) and Harmony Ultimate Home Control or Harmony Home Hub, you can control Insteon lights and appliances directly from your remote control using the Home Control buttons.
Assign Insteon Devices to your Remote's Home Control Buttons
Step 1
From the Harmony app, open the settings drawer
Step 2
Tap Harmony Setup
Step 3
Tap Add/Edit Devices & Activities
Step 4
From the Settings screen, scroll down and select Remote & Hub
Step 5
Tap Harmony Home Control Button Customization
Step 6
Tap Home Control Buttons
Step 7
Tap the button for which you would like to assign an Insteon device and then tap the Assign button to chose an Insteon light or appliance.
Repeat these steps for the four Home Control buttons and, when finished, tap the next arrow.